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The XVIIth Cochrane Colloquium in Singapore

The Cochrane Collaboration’s XVIIth Cochrane Colloquium in Singapore

Donald Patrick, PhD, MSPH
1| Gordon Guyatt, PhD 2
1 University of Washington, Seattle, Washington, USA
 2 McMaster University , hamilton, Ontario, Canada



Co-Convenors Donald Patrick and Gord Guyatt attended the XVII Cochrane Colloquium held in the Lion City State of Singapore (11–14 October). Approximately 650 persons attended the first Asian meeting of the Colloquium in its history.

Members Caroline Terwee and Rieke (H.C.) de Vet along with Gordon and Donald presented a workshop on “How to

incorporate patient-reported outcomes into Cochrane reviews”. At that workshop a Cochrane review on urinary incontinence was presented and suggestions were made on how to improve the review and how to calculate and interpret changes scores from the review for completing Summary of Findings tables now being recommended by the Collaboration in advising on the benefits of interventions. Donald with the help of Beng Li from Health Research Associates, Asia presented a workshop on “Cultural adaptation of patient-reported outcomes in systematic reviews: how to evaluate equivalence”. The Chinese translation of a PRO module (again in incontinence) was used to illustrate translation difficulties and possible barriers to pooling data across trials. Gordon also presented two other talks at the meeting entitled “To what extent do trials stopped early for benefit overestimate treatment effects?” (trials stopped early DO overestimate treatment effects) and “Rating quality of evidence using Cochrane/GRADE approach: sub-group analysis” (analysis techniques can matter in grading evidence).


The main objective of the PRO Methods Group is to advise Cochrane reviewers about when and how to incorporate

PROs into systematic reviews. The group works to :


• refine methods of literature searching on PRO studies
• develop methods for systematically reviewing PRO studies, including identification of concepts, measured in relation to the treatments being evaluated and statements on treatment benefit
• refine methods for meta-analysis of PRO studies (in collaboration with the Statistics MG)
• advise on software development
• refine methods for presentation of PRO results inSummary of Findings tables in collaboration with the GRADE MG


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