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Development and Validation of the Celiac Disease Questionnaire (CDQ), a Disease- specific Measure of Health- Related Quality of Life Measure for Adult Patients with Celiac Disease


Winfried Häuser, M.D

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Department Internal Medicine I, Klinikum Saarbrücken, D- 66119 Saarbrücken, Germany

Keywords: health-related quality of life (HRQL), celiac disease, CDQ questionnaire, validation, questionnaire development



Based on a Medline search, responses from 10 celiac disease (CD)-patients and four medical experts items potentially affecting health related quality of life (HRQOL) in celiac disease were identified and a preliminary version of the Celiac Disease Questionnaire CDQ was constructed. The CDQ was validated in a national survey involving 522 respondents of 1000 CD-patients (Median age 45 years; 78% female) posted by the German Celiac Society. Subscales were constructed by a principle factor analysis following predefined criteria and validated with other HRQOL-measures. Factor analysis suggested four domains with seven items each: Emotional and social problems, disease related worries and gastrointestinal symptoms. The psychometric properties of the CDQ were good.



In this article we describe the development and validation of the first disease-specific questionnaire to measure health-related quality of life (HRQOL) in adult patients with celiac disease (CD) – The Celiac Disease Questionnaire CDQ1 following established criteria for the development of HRQOL-instruments2,3.



Study design

The instrument was developed together with the German Celiac Society DZG. The development of the instrument was embedded in the first German survey on celiac disease4.


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