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Reliability and Validity of the PedsQL™ 4.0 Generic Core Scales Young Adult Version

James W. Varni, Ph.D.1 | Christine A. Limbers, M.S.2
1 Department of Pediatrics, College of Medicine, Department of Landscape Architecture and Urban Planning, College of Architecture, Texas A&M University, College Station, Texas, USA
2 Department of Psychology, College of Liberal Arts, Texas A&M University, College Station, Texas, USA

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Key Words:  PedsQL™, young adult, self-report, university students, patient-reported outcomes, health-related quality of life 


There are a substantial number of pediatric patients with chronic health conditions who choose to remain with their pediatric providers after they reach 18 years of age.  The PedsQL™ 4.0 Generic Core Scales Young Adult Version was developed to facilitate the evaluation of differences in HRQOL across and between pediatric age groups, as well as the tracking of HRQOL longitudinally, while maintaining scale construct consistency.  The 23-item PedsQL™ 4.0 Generic Core Scales Young Adult Version and the SF-8™ Health Survey were completed by 1,256 undergraduate students ages 18-25 enrolled in a large state university. The PedsQL™ 4.0 Young Adult Version demonstrated excellent reliability for the Total Scale Score (α = 0.86), differentiated between healthy university students and university students with a chronic health condition, and was significantly correlated with the SF-8™. The results demonstrate the reliability and validity of the PedsQL™ 4.0 Generic Core Scales Young Adult Version.           


Pediatric Patient Reported Outcomes (PROs)
The measurement of pediatric health-related quality of life (HRQOL) in pediatric medicine and health services research has grown dramatically over the past decade [1, 2].  Recent legislative changes have produced both voluntary and mandatory guidelines for drug studies in children, resulting in a substantial increase in pediatric clinical trials [3].  While HRQOL measurement has been advocated in pediatric clinical trials [4], the emerging paradigm shift toward patient-reported outcomes (PROs) in clinical trials [3] has provided the opportunity to further emphasize the value and critical need for pediatric patient self-report measurement as efficacy outcomes in clinical trials [5-8].


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